Dynamic regulation of mRNA decay during neural development
نویسندگان
چکیده
منابع مشابه
Dynamic profiling of mRNA turnover reveals gene-specific and system-wide regulation of mRNA decay
RNA levels are determined by the rates of both transcription and decay, and a mechanistic understanding of the complex networks regulating gene expression requires methods that allow dynamic measurements of transcription and decay in living cells with minimal perturbation. Here, we describe a metabolic pulse-chase labeling protocol using 4-thiouracil combined with large-scale RNA sequencing to ...
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ژورنال
عنوان ژورنال: Neural Development
سال: 2015
ISSN: 1749-8104
DOI: 10.1186/s13064-015-0038-6